THE SULLIVAN LAB
"The more intelligent the question we ask of Mother Nature,
the more intelligent will be her reply."
-- Sir Charles Sherrington
WHAT DO WE DO?
We study the regulation of gene expression in a fascinating protozoan parasite
called Toxoplasma gondii. Toxoplasma, a relative of the malarial parasite,
causes congenital birth defects, as well as opportunistic infection in AIDS,
cancer chemotherapy, and organ transplant patients. There is also emerging evidence that suggests
this parasite is linked to neurological disorders, such as schizophrenia and behavior modification.
We hypothesize that the proteins controlling gene expression at epigenetic, transcriptional,
and translational levels may represent novel drug targets to fight Toxoplasma
and other infectious diseases.
More about what we do can be read in this news article
Shown here are Toxoplasma parasites inside
human fibroblast cells
Follow the links below for more about...
Lab Tools & Resources
Publications & Dissertations
**Visit The Toxoplasma News Blog**
We are currently seeking a postdoctoral fellow; click here for details
Congratulations to Krista (now Dr. Stilger) for passing her Ph.D. thesis defense! (October 31, 2013)
New publication: " GCN2-like eIF2α kinase manages the amino acid starvation response in Toxoplasma gondii" (IJP, 2013)
Dr. Sullivan wrote an article for ASBMB Today entitled, "How to write a killer cover letter for a postdoctoral application" - you can read it here.
New publication: "Elp3 lysine acetyltransferase is a tail-anchored mitochondrial protein in Toxoplasma gondii" (JBC, 2013)
Christian Konrad's recent research is featured in this news article at Vital Signs
Also highlighted in this edition of INScope
Vicki Jeffers won best overall presentation at the 2013 12th International Congress on Toxoplasmosis
New publication: "Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development." (Molecular Microbiology, 2013)
Krista Stilger received the 2013 K.K. Chen Award in Pharmacology & Toxicology
New publication: "The Unfolded Protein Response in the protozoan parasite Toxoplasma gondii features translational and transcriptional control." (Eukaryotic Cell, 2013)
Jiachen Wang completed her MS degree (May, 2013)
Vicki Jeffers is an invited speaker at the 2013 International Congress on Toxoplasmosis (June, 2013)
New publication: "ApiAP2 transcription factor restricts development of the Toxoplasma tissue cyst." (PNAS, 2013)
New publication: "Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii." (Molecular BioSystems, 2013)
New publication: "Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii." (Antimicrobial Agents & Chemotherapy, 2013)
New publication: "Perturbations of Plasmodium Puf2 Expression and RNA-seq of Puf2-Deficient Sporozoites Reveal a Critical Role in Maintaining RNA Homeostasis and Parasite Transmissibility." (Cellular Micro, 2013)
New publication: "Translational control in Plasmodium and Toxoplasma parasites." (Eukaryotic Cell, 2013)
New publication: "Toxoplasma histone acetylation remodelers as novel drug targets." (Expert Rev Anti Infect Ther., 2012)
Vicki Jeffers was an invited speaker at the 2012 ASBMB Post-Translational Modifications meeting in Tahoe City, CA (October, 2012)
Christian Konrad was an invited speaker at the Molecular Parasitology Meeting in Woods Hole, MA (Sept, 2012)
Krista Stilger received a predoctoral fellowship award from the AHA (June, 2012)
Krista Stilger received an IUPUI Travel Fellowship Award (May, 2012)
Stacy Dixon graduated with her MD/PhD May 2012, and was the recipient of the 2012 K.K. Chen Award in Pharmacology & Toxicology
New publication: "Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii" (Eukaryotic Cell, 2012)
Dr. Sullivan received the 2012 Trustee Teaching Award
WHERE ARE WE?
Indiana University School of Medicine
Dept of Pharmacology & Toxicology
Dept of Microbiology and Immunology
635 Barnhill Drive, MS A-515
Indianapolis, IN 46202, USA
Click here for more about Indianapolis
Tweets by @wjsullivan
CONTACT: email@example.com Last update: Nov, 2013