THE SULLIVAN LAB
"The more intelligent the question we ask of Mother Nature,
the more intelligent will be her reply."
-- Sir Charles Sherrington
WHAT DO WE DO?
We study the regulation of gene expression in a fascinating protozoan parasite
called Toxoplasma gondii. Toxoplasma, a relative of the malarial parasite,
causes congenital birth defects, as well as opportunistic infection in AIDS,
cancer chemotherapy, and organ transplant patients. There is also emerging evidence that suggests
this parasite is linked to neurological disorders, such as schizophrenia and behavior modification.
We hypothesize that the proteins controlling gene expression at epigenetic, transcriptional,
and translational levels may represent novel drug targets to fight Toxoplasma
and other infectious diseases.
More about what we do can be read in this news article
Shown here are Toxoplasma parasites inside
human fibroblast cells
Follow the links below for more about...
Lab Tools & Resources
Publications & Dissertations
**Visit The Toxoplasma News Blog**
Dr. Sullivan's new article, "Taming the Wild West: Social Media for Scientists" has been published at The Postdoc Way.
New publication: "Lysine Acetyltransferase GCN5b Interacts with AP2 Factors and Is Required for Toxoplasma gondii Proliferation” in PLoS Pathogens (January, 2014).
Our study, “Elongator Protein 3 (Elp3) Lysine Acetyltransferase Is a Tail-anchored Mitochondrial Protein in Toxoplasma gondii” was featured in ASBMB Today (January, 2014).
Dr. Sullivan’s article “How to write a killer cover letter for a postdoctoral application” published in ASBMB Today was the second most-read article in 2013.
Dr. Sullivan’s article, “Back to the 80s: The Top Ten 80s Songs for Your Lab Playlist" was published at BitesizeBio (December, 2013)
Vicki Jeffers received a postdoctoral fellowship award from the AHA (December, 2013)
New publication: "The histone code of Toxoplasma gondii comprises conserved and unique post-translational modifications" in mBio (December, 2013)
Congratulations to Krista (now Dr. Stilger) for passing her Ph.D. thesis defense! (October 31, 2013)
New publication: " GCN2-like eIF2α kinase manages the amino acid starvation response in Toxoplasma gondii" (IJP, 2013)
Dr. Sullivan wrote an article for ASBMB Today entitled, "How to write a killer cover letter for a postdoctoral application" - you can read it here.
New publication: "Elp3 lysine acetyltransferase is a tail-anchored mitochondrial protein in Toxoplasma gondii" (JBC, 2013)
Christian Konrad's recent research is featured in this news article at Vital Signs
Also highlighted in this edition of INScope
Vicki Jeffers won best overall presentation at the 2013 12th International Congress on Toxoplasmosis
New publication: "Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development." (Molecular Microbiology, 2013)
Krista Stilger received the 2013 K.K. Chen Award in Pharmacology & Toxicology
New publication: "The Unfolded Protein Response in the protozoan parasite Toxoplasma gondii features translational and transcriptional control." (Eukaryotic Cell, 2013)
Jiachen Wang completed her MS degree (May, 2013)
Vicki Jeffers is an invited speaker at the 2013 International Congress on Toxoplasmosis (June, 2013)
New publication: "ApiAP2 transcription factor restricts development of the Toxoplasma tissue cyst." (PNAS, 2013)
New publication: "Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii." (Molecular BioSystems, 2013)
New publication: "Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii." (Antimicrobial Agents & Chemotherapy, 2013)
New publication: "Perturbations of Plasmodium Puf2 Expression and RNA-seq of Puf2-Deficient Sporozoites Reveal a Critical Role in Maintaining RNA Homeostasis and Parasite Transmissibility." (Cellular Micro, 2013)
New publication: "Translational control in Plasmodium and Toxoplasma parasites." (Eukaryotic Cell, 2013)
WHERE ARE WE?
Indiana University School of Medicine
Dept of Pharmacology & Toxicology
Dept of Microbiology and Immunology
635 Barnhill Drive, MS A-515
Indianapolis, IN 46202, USA
Click here for more about Indianapolis
Tweets by @wjsullivan
CONTACT: email@example.com Last update: January, 2014