Publications & Student Dissertations
Zhang M, Fennell C, Ranford-Cartwright L, Sakthivel R, Gueirard P, Meister S, Caspi A, Doerig C, Nussenzweig RS, Tuteja R, Sullivan WJ Jr, Roos DS, Fontoura BM, Ménard R, Winzeler EA, Nussenzweig V. The Plasmodium eukaryotic initiation factor-2{alpha} kinase IK2 controls the latency of sporozoites in the mosquito salivary glands. J Exp Med. 2010 Jun 28. [Epub ahead of print] PMID: 20584882
Dixon SE, Stilger KL, Elias EV, Naguleswaran A, Sullivan WJ Jr. A decade of epigenetic research in Toxoplasma gondii. Mol Biochem Parasitol. 2010 Sep;173(1):1-9. Epub 2010 May 12. PMID: 20470832
Vonlaufen N, Naguleswaran A, Coppens I, Sullivan WJ Jr. MYST family lysine acetyltransferase facilitates ataxia telangiectasia mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondii. J Biol Chem. 2010 Apr 9;285(15):11154-61. Epub 2010 Feb 16. PMID: 20159970
Dalmasso MC, Onyango DO, Naguleswaran A, Sullivan WJ Jr, Angel SO. Toxoplasma H2A variants reveal novel insights into nucleosome composition and functions for this histone family. J Mol Biol. 2009 Sep 11;392(1):33-47. Epub 2009 Jul 14. PMID: 19607843
Sullivan WJ Jr, Smith AT, Joyce BR. Understanding mechanisms and the role of differentiation in pathogenesis of Toxoplasma gondii: a review. Mem Inst Oswaldo Cruz. 2009 Mar;104(2):155-61. PMID: 19430637
Vonlaufen N, Kanzok SM, Wek RC, Sullivan Jr WJ.
Stress response pathways in
protozoan parasites.
Cell Microbiol. 2008 Dec;10(12):2387-99. Epub 2008 Aug 1. Review.
PMID: 18647172
Behnke MS, Radke JB, Smith AT, Sullivan WJ Jr, White MW.
The
transcription of bradyzoite genes in Toxoplasma gondii is controlled by
autonomous promoter elements.
Mol Microbiol. 2008 Jun;68(6):1502-18. Epub 2008 Apr 21.
PMID: 18433450 [PubMed - as supplied by publisher]
Narasimhan J, Joyce BR, Naguleswaran A, Smith AT, Livingston MR, Dixon SE,
Coppens I, Wek RC, Sullivan WJ Jr. Translation regulation by eIF2
kinases in the development of latent cysts in Toxoplasma gondii.
J Biol Chem. 2008 Jun 13;283(24):16591-601. Epub 2008 Apr 16.
PMID: 18420584 [PubMed - as supplied by publisher]
Mohan A, Sullivan WJ Jr, Radivojac P, Dunker AK, Uversky VN. Intrinsic
disorder in pathogenic and non-pathogenic microbes: discovering and analyzing
the unfoldomes of early-branching eukaryotes.
Mol Biosyst. 2008
Apr;4(4):328-40. Epub 2008 Feb 21.
PMID: 18354786
Naguleswaran A, Fialho AM, Chaudhari A, Hong CS, Chakrabarty AM,
Sullivan WJ Jr. Azurin-like protein blocks
invasion of Toxoplasma gondii through potential interactions with parasite
surface antigen SAG1.
Antimicrob Agents Chemother. 2008 Feb;52(2):402-8. Epub 2007 Dec 10.
PMID: 18070964
Meissner M, Agop-Nersesian C, Sullivan WJ Jr. Molecular tools for
analysis of gene function in parasitic microorganisms.
Appl Microbiol Biotechnol. 2007 Jul;75(5):963-75. Epub 2007 Mar
31. Review.
PMID: 17401559
Smith AT, Livingston MR, Mai A, Filetici P, Queener SF, Sullivan WJ Jr.
Quinoline Derivative MC1626, a Putative GCN5 Histone Acetyltransferase
(HAT) Inhibitor, Exhibits HAT-Independent Activity against Toxoplasma gondii.
Antimicrob
Agents Chemother. 2007 Mar;51(3):1109-11. Epub 2006 Dec 18.
PMID: 17178801
Sullivan WJ Jr, Naguleswaran A, Angel SO. Histones and histone
modifications in protozoan parasites.
Cell Microbiol. 2006
8(12):1850-61. Epub 2006 Oct 4.
PMID: 17026479
Sullivan
WJ Jr, Hakimi MA. Histone mediated gene activation in Toxoplasma
gondii.
Mol
Biochem Parasitol. 2006 Aug;148(2):109-16. Epub 2006 Apr 18.
PMID: 16644030
Bhatti
MM, Livingston M, Mullapudi N, Sullivan WJ Jr. Pair of unusual GCN5
histone acetyltransferases and ADA2 homologues in the protozoan parasite
Toxoplasma gondii.
Eukaryot Cell. 2006
Jan;5(1):62-76.
PMID: 16400169
Smith
AT, Tucker-Samaras SD, Fairlamb AH, Sullivan WJ Jr. MYST family
histone acetyltransferases in the protozoan parasite Toxoplasma gondii.
Eukaryot Cell. 2005
Dec;4(12):2057-65.
PMID: 16339723
Saksouk
N, Bhatti MM, Kieffer S, Smith AT, Musset K, Garin J, Sullivan WJ Jr,
Cesbron-Delauw MF, Hakimi MA. Histone-modifying complexes regulate
gene expression pertinent to the differentiation of the protozoan parasite
Toxoplasma gondii.
Mol Cell Biol.
2005 Dec;25(23):10301-14.
PMID: 16287846
Rider
SD Jr, Cai X, Sullivan WJ Jr, Smith AT, Radke J, White M, Zhu G. The
protozoan parasite Cryptosporidium parvum possesses two functionally and
evolutionarily divergent replication protein A large subunits.
J Biol Chem.
2005 Sep 9;280(36):31460-9. Epub 2005 Jul 11.
PMID: 16014411
Sullivan
WJ Jr, Dixon SE, Li C, Striepen B, Queener SF. IMP dehydrogenase from
the protozoan parasite Toxoplasma gondii.
Antimicrob
Agents Chemother. 2005 Jun;49(6):2172-9.
PMID: 15917510
Nallani
KC, Sullivan WJ Jr. Identification of proteins interacting with
Toxoplasma SRCAP by yeast two-hybrid screening.
Parasitol Res. 2005
Mar;95(4):236-42. Epub 2005 Jan 27.
PMID: 15729590
Bhatti
MM, Sullivan WJ Jr. Histone acetylase GCN5 enters the nucleus via
importin-alpha in protozoan parasite Toxoplasma gondii.
J Biol Chem.
2005 Feb 18;280(7):5902-8. Epub 2004 Dec 9.
PMID: 15591057
Chaudhary
K, Darling JA, Fohl LM, Sullivan WJ Jr, Donald RG, Pfefferkorn ER, Ullman B,
Roos DS. Purine salvage pathways in the apicomplexan parasite
Toxoplasma gondii.
J Biol Chem.
2004 Jul 23;279(30):31221-7. Epub 2004 May 11.
PMID: 15140885
Sullivan
WJ Jr, Narasimhan J, Bhatti MM, Wek RC. Parasite-specific eIF2
(eukaryotic initiation factor-2) kinase required for stress-induced translation
control.
Biochem J. 2004
Jun 1;380(Pt 2):523-31.
PMID: 14989696
Sullivan
WJ Jr. Histone H3 and H3.3 variants in the protozoan pathogens
Plasmodium falciparum and Toxoplasma gondii.
DNA
Seq. 2003 Jun;14(3):227-31.
PMID: 14509838
Sullivan
WJ Jr, Monroy MA, Bohne W, Nallani KC, Chrivia J, Yaciuk P, Smith CK 2nd,
Queener SF. Molecular cloning and characterization of an SRCAP
chromatin remodeling homologue in Toxoplasma gondii.
Parasitol Res. 2003
May;90(1):1-8. Epub 2003 Jan 28.
PMID: 12743798
Sullivan
WJ Jr, Smith CK 2nd. Cloning and characterization of a novel histone
acetyltransferase homologue from the protozoan parasite Toxoplasma gondii
reveals a distinct GCN5 family member.
Gene. 2000 Jan 25;242(1-2):193-200.
PMID: 10721712
Roos
DS, Crawford MJ, Donald RG, Fohl LM, Hager KM, Kissinger JC, Reynolds MG,
Striepen B, Sullivan WJ Jr. Transport and trafficking: Toxoplasma as
a model for Plasmodium.
Novartis Found Symp.
1999;226:176-95; discussion 195-8. Review.
PMID: 10645546
Chiang
CW, Carter N, Sullivan WJ Jr, Donald RG, Roos DS, Naguib FN, el Kouni MH, Ullman
B, Wilson CM. The adenosine transporter of Toxoplasma gondii.
Identification by insertional mutagenesis, cloning, and recombinant expression.
J Biol Chem.
1999 Dec 3;274(49):35255-61.
PMID: 10575012
Darling
JA, Sullivan WJ Jr, Carter D, Ullman B, Roos DS. Recombinant
expression, purification, and characterization of Toxoplasma gondii adenosine
kinase.
Mol
Biochem Parasitol. 1999 Sep 20;103(1):15-23.
PMID: 10514077
Sullivan
WJ Jr, Chiang CW, Wilson CM, Naguib FN, el Kouni MH, Donald RG, Roos DS. Insertional
tagging of at least two loci associated with resistance to adenine arabinoside
in Toxoplasma gondii, and cloning of the adenosine kinase locus.
Mol
Biochem Parasitol. 1999 Sep 20;103(1):1-14.
Roos
DS, Sullivan WJ, Striepen B, Bohne W, Donald RG. Tagging genes and
trapping promoters in Toxoplasma gondii by insertional mutagenesis.
Methods. 1997
Oct;13(2):112-22.
PMID: 9405195
Graduate Student Dissertations:
Jiachen Wang (PhD) (began Summer 2010)
Krista Stilger (PhD) (began Summer 2009)
David Onyango (PhD) (began Summer 2007)
Stacy E. Dixon (MD/PhD) Thesis: GCN5-B is a novel nuclear histone acetyltransferase that is crucial for viability in the protozoan parasite Toxoplasma gondii (6-10)
Kelli S. Bramlett, MS Thesis: Involvement of histone acetylation in transcriptional activity of the farnesoid X receptor (7-06)
Aaron T. Smith, MS Thesis: A MYST-family histone acetylase in the protozoan pathogen Toxoplasma gondii (9-05)
Micah M. Bhatti, (MD/PhD) Thesis: Functions of the unique N-terminus of a GCN5 histone acetylase in Toxoplasma gondii (5-05)
Karuna Nallani, MS Thesis: Characterizing an SNF2-family chromatin remodeler in Toxoplasma (7-04)
Thesis committees:
Ziqing Liu (PhD) Mentor: Johnny He
Sulochanadevi Baskaran (PhD) Thesis: Structure and regulation of yeast glycogen synthase (5-10) Mentor: Tom Hurley
Minerva Mercado-Feliciano (PhD) Thesis: Estrogenic activity of the polybrominated biphenyl ether flame retardant mixture DE-71 (10-07) Mentor: Bob Bigsby
Amy Schmidbauer, MS Thesis: Sequence and functional analysis of Schistosoma mansoni cercarial secretions and adult tegument proteins (12-06) Mentor: Sean Mooney
Donghua Cao, MS Thesis: Characterization of indoleamine 2,3-dioxygenase activity in breast cancer cells (8-05) Mentor: Todd Skaar
MS/MS student research:
Apryl Underwood (Spring 2005)
Christina Bennett (Spring 2005)
Independent research (undergraduate):
Krista Podell (Summer 2010)
Kaitlin Flynn (Summer 2009)
Yvelina Ivanova (Fall 2006)
Anita Sivam (Fall 2006)