Publications & Student Dissertations
Lysine Acetyltransferase GCN5b Interacts with AP2 Factors and Is Required for Toxoplasma gondii Proliferation. Wang J, Dixon SE, Ting LM, Liu TK, Jeffers V, Croken MM, Calloway M, Cannella D, Ali Hakimi M, Kim K, Sullivan WJ Jr. PLoS Pathog. 2014 Jan;10(1):e1003830. doi: 10.1371/journal.ppat.1003830. Epub 2014 Jan 2. PMID: 24391497
Nardelli SC, Che FY, Silmon de Monerri
NC, Xiao H, Nieves E, Madrid-Aliste C, Angel SO, Sullivan WJ Jr, Angeletti RH,
Kim K, Weiss LM. The Histone Code of Toxoplasma gondii Comprises Conserved and
Unique Posttranslational Modifications. MBio. 2013 Dec 10;4(6). PMID: 24327343
Konrad C, Wek RC, Sullivan WJ Jr.
GCN2-like eIF2α kinase manages the amino acid starvation response in Toxoplasma
gondii. Int J Parasitol. 2013. In press.
Stilger KL and Sullivan WJ Jr. Elp3 lysine acetyltransferase is a tail-anchored mitochondrial protein in Toxoplasma gondii. J Biol Chem. 2013. 288(35):25318-29. PMID: 23878194
Miao J, Lawrence M, Jeffers V, Zhao F, Parker D, Ge Y, Sullivan WJ Jr, Cui L. Extensive lysine acetylation occurs in evolutionarily conserved metabolic pathways and parasite-specific functions during Plasmodium falciparum intraerythrocytic development. Mol Microbiol. 2013 Jun 24. doi: 10.1111/mmi.12303. [Epub ahead of print]. PMID: 23796209
Joyce BR, Tampaki Z, Kim K, Wek RC,
Sullivan WJ Jr. The Unfolded Protein Response in the protozoan parasite
Toxoplasma gondii features translational and transcriptional control.
Eukaryot Cell. 2013 Jul;12(7):979-89. PMID: 23666622
Radke JB, Lucas O, De Silva EK, Ma Y, Sullivan WJ Jr, Weiss LM, Llinas M, White MW. ApiAP2 transcription factor restricts development of the Toxoplasma tissue cyst. Proc Natl Acad Sci U S A. 2013 2013 Apr 23;110(17):6871-6. PMID: 23572590
Konrad C, Queener SF, Wek RC, Sullivan WJ Jr. Inhibitors of eIF2α Dephosphorylation Slow Replication and Stabilize Latency in Toxoplasma gondii. Antimicrob Agents Chemother. 2013 Apr;57(4):1815-1822. PMID: 23380722
Xue B*, Jeffers V*, Sullivan WJ+, Uversky VN+. Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii. Mol Biosyst. 2013 Apr 5;9(4):645-57. doi: 10.1039/c3mb25517d. PMID: 23403842. * joint first-author, + joint corresponding author.
Lindner SE, Mikolajczak SA, Vaughan AM, Moon W, Joyce BR, Sullivan WJ Jr, Kappe SH. Perturbations of Plasmodium Puf2 Expression and RNA-seq of Puf2-Deficient Sporozoites Reveal a Critical Role in Maintaining RNA Homeostasis and Parasite Transmissibility. Cell Microbiol. 2013 Jan 29. doi: 10.1111/cmi.12116. [Epub ahead of print] PMID: 23356439
Zhang M, Joyce BR, Sullivan WJ Jr, Nussenzweig V. Translational control in Plasmodium and Toxoplasma parasites. Eukaryot Cell. 2013 Feb;12(2):161-7. PMID: 23243065
Vanagas L, Jeffers V, Bogado SS, Dalmasso MC, Sullivan WJ Jr, Angel SO. Toxoplasma histone acetylation remodelers as novel drug targets. Expert Rev Anti Infect Ther. 2012 Oct;10(10):1189-201. PMID: 23199404
Jeffers V and Sullivan WJ Jr. Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii. Eukaryotic Cell. 2012 Jun;11(6):735-42. PMID: 22544907
Zhang M, Mishra S, Sakthivel R, Rojas M, Ranjan R, Sullivan WJ Jr, Fontoura BM, Ménard R, Dever TE, Nussenzweig V. PK4, a eukaryotic initiation factor 2α(eIF2α) kinase, is essential for the development of the erythrocytic cycle of Plasmodium. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3956-61. Epub 2012 Feb 21.PMID: 22355110
Figueras MJ, Martin OA, Echeverria PC, de Miguel N, Naguleswaran A, Sullivan WJ Jr, Corvi MM, Angel SO. Toxoplasma gondii Sis1-like J-domain protein is a cytosolic chaperone associated to HSP90/HSP70 complex. Int J Biol Macromol. 2012 Apr 1;50(3):725-33. Epub 2011 Dec 23. PMID: 22209934
Sullivan WJ Jr, Jeffers V. Mechanisms of Toxoplasma gondii persistence and latency. FEMS Microbiol Rev. 2012 May;36(3):717-33. PMID: 22091606
Konrad C, Wek RC, Sullivan WJ Jr. A GCN2-like eukaryotic initiation factor 2 kinase increases the viability of extracellular Toxoplasma gondii parasites. Eukaryot Cell. 2011 Nov;10(11):1403-12. Epub 2011 Sep 9. PMID: 21908594
Dalmasso MC, Sullivan WJ, Angel SO. Canonical and variant histones of protozoan parasites. Front Biosci. 2011 Jun 1;17:2086-2105. PMID: 21622164
Onyango DO, Naguleswaran A, Delaplane S, Reed A, Kelley MR, Georgiadis MM, Sullivan WJ Jr. Base excision repair apurinic/apyrimidinic endonucleases in apicomplexan parasite Toxoplasma gondii. DNA Repair (Amst). 2011 May 5;10(5):466-75. Epub 2011 Feb 24. PMID:21353648
Joyce BR, Konrad C, Wek RC, Sullivan WJ Jr. Translation control is critical during acute and chronic stages of toxoplasmosis infection. Expert Rev Anti Infect Ther. 2011 Jan;9(1):1-3. PMID: 21171869
Dixon SE, Bhatti MM, Uversky VN, Dunker AK, Sullivan WJ Jr. Regions of intrinsic disorder help identify a novel nuclear localization signal in Toxoplasma gondii histone acetyltransferase TgGCN5-B. Mol Biochem Parasitol. 2011 Feb;175(2):192-5 PMID: 21055425
Naguleswaran A, Elias EV, McClintick J, Edenberg HJ, Sullivan WJ. Toxoplasma gondii Lysine Acetyltransferase GCN5-A Functions in the Cellular Response to Alkaline Stress and Expression of Cyst Genes. PLoS Pathog. 2010 Dec 16;6(12):e1001232. PMID: 21179246
Joyce BR, Queener SF, Wek RC, Sullivan WJ Jr. Phosphorylation of eukaryotic initiation factor-2{alpha} promotes the extracellular survival of obligate intracellular parasite Toxoplasma gondii. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17200-5 PMID: 20855600
Zhang M, Fennell C, Ranford-Cartwright L, Sakthivel R, Gueirard P, Meister S, Caspi A, Doerig C, Nussenzweig RS, Tuteja R, Sullivan WJ Jr, Roos DS, Fontoura BM, Ménard R, Winzeler EA, Nussenzweig V. The Plasmodium eukaryotic initiation factor-2{alpha} kinase IK2 controls the latency of sporozoites in the mosquito salivary glands. J Exp Med. 2010 Jul 5;207(7):1465-74. PMID: 20584882
Dixon SE, Stilger KL, Elias EV, Naguleswaran A, Sullivan WJ Jr. A decade of epigenetic research in Toxoplasma gondii. Mol Biochem Parasitol. 2010 Sep;173(1):1-9. Epub 2010 May 12. PMID: 20470832
Vonlaufen N, Naguleswaran A, Coppens I, Sullivan WJ Jr. MYST family lysine acetyltransferase facilitates ataxia telangiectasia mutated (ATM) kinase-mediated DNA damage response in Toxoplasma gondii. J Biol Chem. 2010 Apr 9;285(15):11154-61. Epub 2010 Feb 16. PMID: 20159970
Dalmasso MC, Onyango DO, Naguleswaran A, Sullivan WJ Jr, Angel SO. Toxoplasma H2A variants reveal novel insights into nucleosome composition and functions for this histone family. J Mol Biol. 2009 Sep 11;392(1):33-47. Epub 2009 Jul 14. PMID: 19607843
Sullivan WJ Jr, Smith AT, Joyce BR. Understanding mechanisms and the role of differentiation in pathogenesis of Toxoplasma gondii: a review. Mem Inst Oswaldo Cruz. 2009 Mar;104(2):155-61. PMID: 19430637
Vonlaufen N, Kanzok SM, Wek RC, Sullivan Jr WJ. Stress response pathways in
protozoan parasites.
Cell Microbiol. 2008 Dec;10(12):2387-99. Epub 2008 Aug 1. Review.
PMID: 18647172
Behnke MS, Radke JB, Smith AT, Sullivan WJ Jr, White MW.
The
transcription of bradyzoite genes in Toxoplasma gondii is controlled by
autonomous promoter elements.
Mol Microbiol. 2008 Jun;68(6):1502-18. Epub 2008 Apr 21.
PMID: 18433450 [PubMed - as supplied by publisher]
Narasimhan J, Joyce BR, Naguleswaran A, Smith AT, Livingston MR, Dixon SE,
Coppens I, Wek RC, Sullivan WJ Jr. Translation regulation by eIF2
kinases in the development of latent cysts in Toxoplasma gondii.
J Biol Chem. 2008 Jun 13;283(24):16591-601. Epub 2008 Apr 16.
PMID: 18420584 [PubMed - as supplied by publisher]
Mohan A, Sullivan WJ Jr, Radivojac P, Dunker AK, Uversky VN. Intrinsic
disorder in pathogenic and non-pathogenic microbes: discovering and analyzing
the unfoldomes of early-branching eukaryotes.
Mol Biosyst. 2008
Apr;4(4):328-40. Epub 2008 Feb 21.
PMID: 18354786
Naguleswaran A, Fialho AM, Chaudhari A, Hong CS, Chakrabarty AM,
Sullivan WJ Jr. Azurin-like protein blocks
invasion of Toxoplasma gondii through potential interactions with parasite
surface antigen SAG1.
Antimicrob Agents Chemother. 2008 Feb;52(2):402-8. Epub 2007 Dec 10.
PMID: 18070964
Meissner M, Agop-Nersesian C, Sullivan WJ Jr. Molecular tools for
analysis of gene function in parasitic microorganisms.
Appl Microbiol Biotechnol. 2007 Jul;75(5):963-75. Epub 2007 Mar
31. Review.
PMID: 17401559
Smith AT, Livingston MR, Mai A, Filetici P, Queener SF, Sullivan WJ Jr.
Quinoline Derivative MC1626, a Putative GCN5 Histone Acetyltransferase
(HAT) Inhibitor, Exhibits HAT-Independent Activity against Toxoplasma gondii.
Antimicrob
Agents Chemother. 2007 Mar;51(3):1109-11. Epub 2006 Dec 18.
PMID: 17178801
Sullivan WJ Jr, Naguleswaran A, Angel SO. Histones and histone
modifications in protozoan parasites.
Cell Microbiol. 2006
8(12):1850-61. Epub 2006 Oct 4.
PMID: 17026479
Sullivan
WJ Jr, Hakimi MA. Histone mediated gene activation in Toxoplasma
gondii.
Mol
Biochem Parasitol. 2006 Aug;148(2):109-16. Epub 2006 Apr 18.
PMID: 16644030
Bhatti
MM, Livingston M, Mullapudi N, Sullivan WJ Jr. Pair of unusual GCN5
histone acetyltransferases and ADA2 homologues in the protozoan parasite
Toxoplasma gondii.
Eukaryot Cell. 2006
Jan;5(1):62-76.
PMID: 16400169
Smith
AT, Tucker-Samaras SD, Fairlamb AH, Sullivan WJ Jr. MYST family
histone acetyltransferases in the protozoan parasite Toxoplasma gondii.
Eukaryot Cell. 2005
Dec;4(12):2057-65.
PMID: 16339723
Saksouk
N, Bhatti MM, Kieffer S, Smith AT, Musset K, Garin J, Sullivan WJ Jr,
Cesbron-Delauw MF, Hakimi MA. Histone-modifying complexes regulate
gene expression pertinent to the differentiation of the protozoan parasite
Toxoplasma gondii.
Mol Cell Biol.
2005 Dec;25(23):10301-14.
PMID: 16287846
Rider
SD Jr, Cai X, Sullivan WJ Jr, Smith AT, Radke J, White M, Zhu G. The
protozoan parasite Cryptosporidium parvum possesses two functionally and
evolutionarily divergent replication protein A large subunits.
J Biol Chem.
2005 Sep 9;280(36):31460-9. Epub 2005 Jul 11.
PMID: 16014411
Sullivan
WJ Jr, Dixon SE, Li C, Striepen B, Queener SF. IMP dehydrogenase from
the protozoan parasite Toxoplasma gondii.
Antimicrob
Agents Chemother. 2005 Jun;49(6):2172-9.
PMID: 15917510
Nallani
KC, Sullivan WJ Jr. Identification of proteins interacting with
Toxoplasma SRCAP by yeast two-hybrid screening.
Parasitol Res. 2005
Mar;95(4):236-42. Epub 2005 Jan 27.
PMID: 15729590
Bhatti
MM, Sullivan WJ Jr. Histone acetylase GCN5 enters the nucleus via
importin-alpha in protozoan parasite Toxoplasma gondii.
J Biol Chem.
2005 Feb 18;280(7):5902-8. Epub 2004 Dec 9.
PMID: 15591057
Chaudhary
K, Darling JA, Fohl LM, Sullivan WJ Jr, Donald RG, Pfefferkorn ER, Ullman B,
Roos DS. Purine salvage pathways in the apicomplexan parasite
Toxoplasma gondii.
J Biol Chem.
2004 Jul 23;279(30):31221-7. Epub 2004 May 11.
PMID: 15140885
Sullivan
WJ Jr, Narasimhan J, Bhatti MM, Wek RC. Parasite-specific eIF2
(eukaryotic initiation factor-2) kinase required for stress-induced translation
control.
Biochem J. 2004
Jun 1;380(Pt 2):523-31.
PMID: 14989696
Sullivan
WJ Jr. Histone H3 and H3.3 variants in the protozoan pathogens
Plasmodium falciparum and Toxoplasma gondii.
DNA
Seq. 2003 Jun;14(3):227-31.
PMID: 14509838
Sullivan
WJ Jr, Monroy MA, Bohne W, Nallani KC, Chrivia J, Yaciuk P, Smith CK 2nd,
Queener SF. Molecular cloning and characterization of an SRCAP
chromatin remodeling homologue in Toxoplasma gondii.
Parasitol Res. 2003
May;90(1):1-8. Epub 2003 Jan 28.
PMID: 12743798
Sullivan
WJ Jr, Smith CK 2nd. Cloning and characterization of a novel histone
acetyltransferase homologue from the protozoan parasite Toxoplasma gondii
reveals a distinct GCN5 family member.
Gene. 2000 Jan 25;242(1-2):193-200.
PMID: 10721712
Roos
DS, Crawford MJ, Donald RG, Fohl LM, Hager KM, Kissinger JC, Reynolds MG,
Striepen B, Sullivan WJ Jr. Transport and trafficking: Toxoplasma as
a model for Plasmodium.
Novartis Found Symp.
1999;226:176-95; discussion 195-8. Review.
PMID: 10645546
Chiang
CW, Carter N, Sullivan WJ Jr, Donald RG, Roos DS, Naguib FN, el Kouni MH, Ullman
B, Wilson CM. The adenosine transporter of Toxoplasma gondii.
Identification by insertional mutagenesis, cloning, and recombinant expression.
J Biol Chem.
1999 Dec 3;274(49):35255-61.
PMID: 10575012
Darling
JA, Sullivan WJ Jr, Carter D, Ullman B, Roos DS. Recombinant
expression, purification, and characterization of Toxoplasma gondii adenosine
kinase.
Mol
Biochem Parasitol. 1999 Sep 20;103(1):15-23.
PMID: 10514077
Sullivan
WJ Jr, Chiang CW, Wilson CM, Naguib FN, el Kouni MH, Donald RG, Roos DS. Insertional
tagging of at least two loci associated with resistance to adenine arabinoside
in Toxoplasma gondii, and cloning of the adenosine kinase locus.
Mol
Biochem Parasitol. 1999 Sep 20;103(1):1-14.
Roos
DS, Sullivan WJ, Striepen B, Bohne W, Donald RG. Tagging genes and
trapping promoters in Toxoplasma gondii by insertional mutagenesis.
Methods. 1997
Oct;13(2):112-22.
PMID: 9405195
Graduate Student Dissertations:
Sherri Huang (MD/PhD) (began Summer 2013)
Joseph Varberg (PhD) (began Summer 2013)
Leah Padgett (PhD) (began Summer 2013)
Krista Stilger (PhD) Thesis: Identification of TgElp3 as an essential, tail-anchored mitochondrial lysine acetyltransferase in the protozoan pathogen Toxoplasma (10-13)
Jiachen Wang (MS) Thesis: Lysine acetyltransferase GCN5-B regulates the expression of crucial genes in Toxoplasma (5-13)
David Onyango (PhD) Thesis: Base excision repair apurinic/apyrimidinic endonucleases in apicomplexan parasite Toxoplasma gondii (1-11)
Stacy E. Dixon (MD/PhD) Thesis: GCN5-B is a novel nuclear histone acetyltransferase that is crucial for viability in the protozoan parasite Toxoplasma gondii (6-10)
Kelli S. Bramlett, MS Thesis: Involvement of histone acetylation in transcriptional activity of the farnesoid X receptor (7-06)
Aaron T. Smith, MS Thesis: A MYST-family histone acetylase in the protozoan pathogen Toxoplasma gondii (9-05)
Micah M. Bhatti, (MD/PhD) Thesis: Functions of the unique N-terminus of a GCN5 histone acetylase in Toxoplasma gondii (5-05)
Karuna Nallani, MS Thesis: Characterizing an SNF2-family chromatin remodeler in Toxoplasma (7-04)
Thesis committees:
Sara Culleton (MD/PhD) Mentor: Elliot Androphy
Cindy Morgan (PhD) Mentor: Tom Hurley
Li Qin (PhD) Mentor: JT Zhang
Ziqing Liu (PhD) Thesis: Characterization of hepatitis C virus infection of hepatocytes and astrocytes (8-13) Mentor: Johnny He
Natalia VanDuyn (PhD) Thesis: Identification and characterization of molecular modulators of methylmercury-induced toxicity and dopamine neuron degeneration in Caenorhabditis elegans (7-13) Mentor: Richard Nass
Sulochanadevi Baskaran (PhD) Thesis: Structure and regulation of yeast glycogen synthase (5-10) Mentor: Tom Hurley
Minerva Mercado-Feliciano (PhD) Thesis: Estrogenic activity of the polybrominated biphenyl ether flame retardant mixture DE-71 (10-07) Mentor: Bob Bigsby
Amy Schmidbauer, MS Thesis: Sequence and functional analysis of Schistosoma mansoni cercarial secretions and adult tegument proteins (12-06) Mentor: Sean Mooney
Donghua Cao, MS Thesis: Characterization of indoleamine 2,3-dioxygenase activity in breast cancer cells (8-05) Mentor: Todd Skaar
MS/MS student research:
Apryl Underwood (Spring 2005)
Christina Bennett (Spring 2005)
Independent research (undergraduate):
Nic Wheeler (2011-12)
Krista Podell (Summer 2010)
Kaitlin Flynn (Summer 2009)
Yvelina Ivanova (Fall 2006)
Anita Sivam (Fall 2006)